What is Rapamycin ?
Rapamycin (Sirolimus) is an mTOR inhibitor traditionally used as an immunosuppressant in transplant medicine. In recent years, it has gained growing interest in the field of longevity and anti-aging medicine due to its ability to modulate cellular aging, inflammation, and metabolic health. When dosed intermittently and at low levels, Rapamycin may help extend lifespan, delay age-related disease onset, and support health span without the immune suppression associated with high-dose use.
Benefits:
- May extend lifespan and delay age-related disease
- Supports cellular autophagy and DNA repair
- Reduces chronic inflammation (“inflammaging”)
- Improves metabolic health and insulin sensitivity
- Works synergistically with fasting, exercise, and AMPK activators (e.g., Metformin)
How does it work ?
Rapamycin works by selectively inhibiting the mammalian target of rapamycin complex 1 (mTORC1), a key regulator of aging and growth:
- mTORC1 Inhibition
• mTORC1 controls cell growth, proliferation, and protein synthesis. Rapamycin slows this pathway, promoting cellular repair, autophagy, and metabolic efficiency—hallmarks of anti-aging.
Intermittent, Low-Dose Strategy
• When used once or twice weekly at low doses, it avoids immunosuppression while preserving its anti-aging and regenerative benefits.
How it works
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